Abstract
The advent of 2nd generation, low-cost, DNA sequencing technologies is leading to dramatic increases in the rate of genome data generation. The utilization of these new technologies to sequence ever increasing numbers of human genomes for personalized diagnostics and medicines will generate even more data. Current database and software technologies are becoming progressively ineffective for managing, processing and analyzing these new levels of information. Synamatix addresses this need by leveraging SynaBASE?, which is an innovative database solution based upon indexing patterns in data. Rapid cross referencing of clinical patient sequence data back to the human genome is a critical step in SNP discovery and identifying potential disease states. Performance improvements of between 100 and 10,000 fold for comparative and differential genomics and for mapping-based genome assembly from 2nd generation sequencers will be reviewed.